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M9470002.TXT
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1994-07-02
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Document 0002
DOCN M9470002
TI Salmonella typhimurium activates human immunodeficiency virus type 1 in
chronically infected promonocytic cells by inducing tumor necrosis
factor-alpha production.
DT 9409
AU Andreana A; Gollapudi S; Kim CH; Gupta S; Division of Basic and Clinical
Immunology, University of; California, Irvine 92717.
SO Biochem Biophys Res Commun. 1994 May 30;201(1):16-23. Unique Identifier
: AIDSLINE MED/94256973
AB The effect of phagocytosis of Salmonella typhimurium on human
immunodeficiency virus type 1 (HIV-1) production was investigated using
a chronically infected promonocytic cell line (U1) that contains HIV-1
provirus but produces little or no HIV-1. The phagocytosis of virulent
S. typhimurium by U1 cells resulted in an increased HIV-1 expression as
evidenced by significant increase in HIV-1 p24 antigen in culture
supernatants. In contrast, heat-killed S. typhimurium failed to induce
HIV-1 expression. In addition, phagocytosis of virulent S. typhimurium
and not of heat-killed S. typhimurium resulted in a significant
induction of tumor necrosis factor-alpha (TNF-alpha) mRNA expression and
secretion of TNF-alpha by U1 cells. Furthermore, anti-TNF-alpha
monoclonal antibody inhibited S. typhimurium-induced HIV-1 p24 antigen
production. These data suggest that S. typhimurium induces HIV-1
expression in U1 cells via production of TNF-alpha.
DE Cell Line Gene Expression Human HIV Core Protein p24/METABOLISM HIV
Infections/*COMPLICATIONS HIV-1/*GROWTH & DEVELOPMENT
Monocytes/MICROBIOLOGY Phagocytosis RNA, Messenger/GENETICS
Salmonella typhimurium/*IMMUNOLOGY Salmonella
Infections/COMPLICATIONS/*IMMUNOLOGY Support, Non-U.S. Gov't Tumor
Necrosis Factor/GENETICS/*METABOLISM Virus Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).